Abstract. Governments continue to play a central role in the way research is conducted and organized by defining new models for research centers. How do existing research centers adapt to changes in their environment? Institutional theory suggests that organizations pursue efficiency and legitimacy by conforming to isomorphic pressures in their organizational field, which will eventually lead to a reduction of diversity in organizational practices and strategies. Resource-dependence theory assumes a more active agency and calls attention to the diverse strategic responses of organizations to institutional processes. Based on funding microdata and qualitative information at center level, this study undertakes to analyze changes in two populations of Spanish research centers (government laboratories and technology centers) in a time of evolving policy paradigms, emergence of new models for research centers, and increasing competition in the field of R&D. We find that a large share of the existing government laboratories and technology centers have progressively conformed to a funding strategy based on diversifying sources and increasing competitive public funding, although both populations are still characterized by some degree of internal diversity regarding funding portfolios. Structural heterogeneity also remains as regards management practices such as research planning and agenda setting.