Abstract. To analyze the prevalence of burnout syndrome in primary care professionals working in the National Health System. We searched PubMed/MEDLINE, EMBASE, and PsycINFO (up to May 2025). Observational studies conducted in Spain reporting the prevalence of burnout in professionals working in primary care (e.g., physicians, nurses, administrative staff and others) were included. From each study, methodological characteristics and results were extracted and their quality was evaluated. We performed a narrative synthesis with random effects meta-analysis to calculate proportions.